Pathological autophagy augments cell death in the diabetic heart

Diabetic heart disease (DHD) is one of the major causes of mortality and morbidity in people with diabetes. DHD is characterised by the excessive loss of cardiovascular cells including cardiac stem cells. However, the exact mechanism leading to this loss remains unknown. Autophagy is a cellular degradation pathway that plays an important role in cellular homeostasis which becomes pathological when the balance is lost. Our recent studies conducted using mouse model of type-2 diabetes showed pathological autophagy in the diabetic heart.

E. Munasinghe, I. Fomison-Nurse, G. Hughes, P. Saxena, R. Bunton, I. Galvin, R. Katare
Heart, Lung and Circulation – Volume 23, Supplement 1, e1-e48
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